Journal of Pure and Applied MicrobiologyVol. 2 No. 2

Antioxidant and Cytotoxic Activity of Compounds from Streptomyces albidoflavus

K.J.P. Narayana¹, B. Hari Babu² and M. Vijayalakshmi¹

¹Department of Microbiology, 2Department of Chemistry, Acharya Nagarjuna University, Guntur - 522 510, India.15 June 2008

Received on 15 June 2008 and accepted on 23 August 2008

 

ABSTRACT

Attempts were made to study the antioxidant and cytotoxic activities of compounds produced by Streptomyces albidoflavus. Bioactive metabolites were obtained from the crude solvent extract of culture broth collected after five days incubation of the strain. Two bioactive compounds were purified and characterized as anthracene-9,10-quinone and 8-hydroxyquinoline. Antioxidant activity of these compounds was studied by superoxide free radical scavenging activity. The compound 8-hydroxyquinoline exhibited good antioxidant properties over BHA but less activity than vitamin C. Cytotoxicity of the compounds was tested on U-937, HeLa and THP-1 cell lines. Of the two bioactive compounds isolated from strain, 8-hydroxyquinoline was found to possess significant cytotoxicity on tested cell lines.

Keywords : Streptomyces albidoflavus Antioxidant activity, Cytotoxicity.