Journal of Pure and Applied MicrobiologyVol. 7 No. Special Edition

Obstructive Sleep Apnea and Glucose Metabolism Disorders

Lu-lu Li, Qiang Zhang*, Jin Tan* and Yun-yun Fang1

1Tianjin Medical University, *Institute of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.

Received on 03 March 2013 and accepted on 14 April 2013

 

ABSTRACT

Obstructive sleep apnea (OSA) is characterized by repetitive upper airway closures or partial collapses that occur during sleep. Evidence from well-defined studies has shown that OSA is associated with increased incidence of diabetes. In this article, we will review the current evidence that links OSA to glucose metabolism disorders, discuss the potential mechanisms by which OSA may contribute to the development of glucose metabolism disorders, and summarize briefly the studies on the impact of treatment of OSA on glucose metabolism.

Keywords : Obstructive Sleep Apnea, glucose metabolism disorders, type 2 diabetics, CPAP, sympathetic nervous system activity, sleep fragmentation, oxidative stress, Inflammatory mediators.