Journal of Pure and Applied MicrobiologyVol. 7 No. 1

Role of Immunoglobulin G and A in Periodontitis: A Review

Reena Kulshrestha1-2*, T.S. Srinivasa2 and Jayant Biswas3

1Faculty of Life Science, MATS University, Raipur, India 2Department of Periodontics, Rungta College of Dental Sciences & Research, Bhilai, India. 3Central Laboratory, National Cave Research and Protection Organization, Raipur, India.

Received on 12 August 2012 and accepted on 24 September 2012



A highly discriminatory immune system is fundamental to survival. The Immune system has a powerful collection of defense mechanisms to protect against potential invaders that would otherwise take advantage of the rich source of nutrients provided by the vertebrate host. Unlike the cells of liver, heart or lungs, the cells of the immune system are scattered throughout the body. They are present in the spleen, lymph nodes, bone marrow, and thymus & circulate through the blood and lymphatic fluid. The first line of defense is provided by the intact skin and mucous membranes of the body. There are a group of proteins (immunoglobulins) present in normal adult, they are of five types IgG, IgA, IgM, IgD, IgE. Amongst these IgG and IgA play important role in Periodontitis as IgG are the main circulating antibody in the blood and can pass from blood into tissue spaces whereas IgA protection to mucosal surfaces.

Keywords : Immunoglobulins, pathogens, periodontitis.