ISSN: 0973-7510

E-ISSN: 2581-690X

Short Communication | Open Access

Aditya Saxena1, Uma Chaudhary1, Alok Bharadwaj1, Nitin Wahi2, Jitender Reddy Kalli3, Shravya Gupta3, Sparsh Kumar3, Somya Gupta3 and Utkarsh Raj3

1Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura – 281 406, India.
2Department of Bioinformatics, Pathfinder Research and Training Foundation, Gr. Noida – 201 308, India.
3Department of Biotechnology and Bioinformatics, NIIT University, Neemrana – 301 705, Rajasthan, India.
J Pure Appl Microbiol. 2020;14(suppl 1):1077-1081 | Article Number: 6324
Received: 02/05/2020 | Accepted: 09/05/2020 | Published: 14/05/2020
Abstract

Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan, China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) which causes zoonotic sicknesses and represents a significant risk to general wellbeing. Recognizing the hidden biology and pathogenesis of this novel coronavirus is extremely critical to comprehend as well as boosting the treatment of this deadly pandemic. The point of this study is to recognize key genes which show significant expression in the SARS-CoV-2 infected lungs as compared to healthy ones. Our analysis uncovered 149 gene-signatures that show substantial up-regulation in COVID-19 lungs. Out of these, top ten dysregulated genes STAP1, CASP5, FDCSP, CARD17, ST20, AKR1B10, CLC, KCNJ2-AS1, RNASE2 and FLG are found to be significant based on various crucial statistical factors and may end up being acceptable helpful drug targets.

Keywords

SARS-CoV-2, COVID-19, gene signatures

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