ISSN: 0973-7510
E-ISSN: 2581-690X
, Saipriya C.2, Durga Sruthi P.2, A. Jenifer Selvarani2, Raji P.2, Prakash P.2, Paulraj Ponnaiah1, Thirumurugan R.3, Sajeesh Pattammadath1, Sajna Keeyari Purayil1, Pazhayakath Thevarkattil Mohamed Javad1 and Iyappan P1In this study, SPIONs were produced in the presence of cobalt as catalyst. SPIONs formed by this chemical co-precipitation were size around 20 nm. After producing the SPIONs, it was subjected for functionalization with oleic acid and loaded with drug – itraconazole (a drug possess antifungal and antibacterial activity) and encapsulated with polyhydroxybutyrate (PHB). The produced core-shell SPIONS was used for antimicrobial study against two bacteria namely – Pseudomonas aeruginosa and Brevibacillus brevis and a fungi – Candida albicans. It was found to be effectively releasing drug for more than 3 hours. The SPIONs alone was acting good as contrasting agent and used for enhancing X-ray imaging.
SPIONs, PHB, drug release, X-ray imaging
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