ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Antony V. Samrot1 , Saipriya C.2, Durga Sruthi P.2, A. Jenifer Selvarani2, Raji P.2, Prakash P.2, Paulraj Ponnaiah1, Thirumurugan R.3, Sajeesh Pattammadath1, Sajna Keeyari Purayil1, Pazhayakath Thevarkattil Mohamed Javad1 and Iyappan P1
1School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor – 42610, Malaysia.
2Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai – 600 119, Tamil Nadu, India.
3Department of Transfusion Medicine, JIPMER, Puducherry – 605 006, India.
J Pure Appl Microbiol. 2020;14(2):1317-1322 | Article Number: 5951
https://doi.org/10.22207/JPAM.14.2.27 | © The Author(s). 2020
Received: 18/11/2019 | Accepted: 04/04/2020 | Published: 25/06/2020
Abstract

In this study, SPIONs were produced in the presence of cobalt as catalyst. SPIONs formed by this chemical co-precipitation were size around 20 nm. After producing the SPIONs, it was subjected for functionalization with oleic acid and loaded with drug – itraconazole (a drug possess antifungal and antibacterial activity) and encapsulated with polyhydroxybutyrate (PHB). The produced core-shell SPIONS was used for antimicrobial study against two bacteria namely – Pseudomonas aeruginosa and Brevibacillus brevis and a fungi – Candida albicans. It was found to be effectively releasing drug for more than 3 hours. The SPIONs alone was acting good as contrasting agent and used for enhancing X-ray imaging.

Keywords

SPIONs, PHB, drug release, X-ray imaging

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