Journal of Pure and Applied MicrobiologyVol. 11 No. 1

Antimicrobial activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

Aqeela Shaheen1,2, Shahbaz Akhtar3, Sajjad Ahmad1, Aziz-ur-Rehman1*, Abdul Saeed4, Adnan Sharif1, Mujahid Mustaqeem1, Muhammad Nawaz5 and Syed Tahir Abbas Shah6

1Department Of Chemistry, The Islamia University of Bahawalpur, 63100, Bahawalpur Pakistan. 2Department of Chemistry, Government Sadiq College Women University Bahawalpur, 63100, Bahawalpur Pakistan. 3Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, 63100, Bahawalpur, Pakistan. 4Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Multan Pakistan. 5Department of Environmental Sciences, Bahauddin Zakariya University, Multan, 60800, Multan Pakistan. 6Department of Biosciences, COMSATS Institute of Information Technology, Islamabad. 45550, Islamabad Pakistan.

Received on 13 October 2016 and accepted on 19 December 2016

 

ABSTRACT

An efficient and facile method for the synthesis of 2-hydroxy-Ní-{(E)-[6'-(2H-1",2",3"-triazol-2"-yl)pyridin-3'-yl]methylidene}benzohydrazide via N-arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.

Keywords : N-arylation, organotin(IV), 1,2,3-triazol, 2-hydroxybenzohydrazide.