Journal of Pure and Applied MicrobiologyVol. 11 No. 1

Status of Diphtheria Immunity Among Saudi Population

Al-Rashedi Mohammed1, Elrashdy M. Redwan1,2 and Hussein A. Almehdar1

1Department of Biological Sciences, King Abdul Aziz University, Jeddah. KSA. 2 Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg EL-Arab 21934, Alexandria, Egypt.

Received on 12 October 2016 and accepted on 22 November 2016

 

ABSTRACT

The aim of this study was to determine the prevalence of diphtheria by a cross-sectional in Saudi population. The size of the population consisted of five-hundred healthy subjects from the western regions of Saudi Arabia from six months to 96 years age. ELISA assay kits was used to titers anti-diphtheria IgG. According to the widely used criteria, 31.7% of the total population was susceptible to diphtheria (IgG level <0.15 IU/ml), 15.7% had basic protection (0.151.0 IU/ml), and 52.6% had full protection (>1.0 IU/ml). The majority (82%) of the population from 6 months to 96 years had a protective level of IgG against diphtheria. The frequencies of susceptibility were relatively high in middle-aged periods (30.2 - 37.5% of subjects aged 2150 years). Significantly, more females (20.7%) than males (15%) were unprotected against diphtheria. In conclusion, monitoring immunization status and administering the diphtheria vaccine as required are essential to ensure adequate and long-lasting antibody levels.

Keywords : Diphtheria, Sero-prevalence, Immunity.